Balmer Paul, Cant Andrew J, Borrow Ray
Vaccine Evaluation Unit, Health Protection Agency North West, Manchester Laboratory, Manchester Royal Infirmary, Manchester, UK.
J Clin Pathol. 2007 Apr;60(4):345-50. doi: 10.1136/jcp.2006.041210. Epub 2006 Sep 1.
Measuring and interpretation of the immune response to pneumococcal polysaccharides is a complex field, owing to the diversity of the pneumococcal polysaccharide capsular types, different vaccine formulations including both polysaccharide and conjugate vaccines, diverse pneumococcal serological assays, lack of immunogenicity data for the conjugate in a number of at-risk groups and complex vaccine schedules. Even the reasons for performing pneumococcal serology can be complex, as assays may be performed for one of two reasons: either to assess an individual's immune status to the pneumococcus or to discriminate between normal and abnormal humoral immunity. This review details a history of the pneumococcal serological assays and provides some insight into when serology can prove useful, including vaccination data for certain at-risk groups.
由于肺炎球菌多糖荚膜类型的多样性、包括多糖疫苗和结合疫苗在内的不同疫苗配方、多样的肺炎球菌血清学检测方法、许多高危人群缺乏结合疫苗的免疫原性数据以及复杂的疫苗接种程序，对肺炎球菌多糖的免疫反应进行测量和解读是一个复杂的领域。甚至进行肺炎球菌血清学检测的原因也可能很复杂，因为检测可能出于以下两个原因之一：要么评估个体对肺炎球菌的免疫状态，要么区分正常和异常的体液免疫。本综述详细介绍了肺炎球菌血清学检测的历史，并对血清学何时有用提供了一些见解，包括某些高危人群的疫苗接种数据。
