青光眼视网膜神经节细胞死亡：机制与神经保护策略。
Retinal ganglion cell death in glaucoma: mechanisms and neuroprotective strategies.
作者信息
Kuehn Markus H, Fingert John H, Kwon Young H
机构信息
Department of Ophthalmology and Visual Sciences, University of Iowa Health Care, 200 Hawkins Drive, Iowa City, IA 52242, USA.
出版信息
Ophthalmol Clin North Am. 2005 Sep;18(3):383-95, vi. doi: 10.1016/j.ohc.2005.04.002.
Various cellular and molecular mechanisms that may lead to apoptotic cell death of retinal ganglion cells in glaucoma are discussed. These cellular mechanisms include neurotrophic factor deprivation, ischemia, glial cell activation, glutamate excitotoxicity, and abnormal immune response. Based on experimental and clinical evidence, the rationale for various neuroprotective strategies is described.
本文讨论了青光眼患者视网膜神经节细胞凋亡性细胞死亡可能涉及的多种细胞和分子机制。这些细胞机制包括神经营养因子剥夺、缺血、胶质细胞激活、谷氨酸兴奋性毒性和异常免疫反应。基于实验和临床证据，本文描述了各种神经保护策略的基本原理。
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