Rokicki Wojciech, Dorecka Mariola, Romaniuk Wanda
Katedry i Oddziału Klinicznego Chorób Oczu Slaskiej Akademii Medycznej w Katowicach Z Wojewódzkiego Szpitala Specjalistycznego nr 5 im. Sw. Barbary.
Klin Oczna. 2007;109(7-9):349-52.
Glaucoma is a kind of optic neuropathy where selective retinal ganglion cell loss is the major hallmark. Frequently glaucoma is associated with elevated intraocular pressure, but this condition is neither necessary nor sufficient for onset and progression of the disease. The exact mechanism of ganglion cell death in glaucoma and fully effective treatment of glaucomatous neuropathy still remain unknown. This article is a review of the recent researches relevant to IOP independent risk factors, mechanisms of RGC death and modern potential therapeutic strategies in glaucoma. Part one includes review of blood flow changes, neurotrophic factors deprivation and apoptotic dysregulation findings in glaucoma.
青光眼是一种视神经病变，其主要特征是选择性视网膜神经节细胞丢失。青光眼常与眼内压升高有关，但这种情况对于该疾病的发生和进展既非必要条件也非充分条件。青光眼患者神经节细胞死亡的确切机制以及青光眼性神经病变的完全有效治疗方法仍然未知。本文综述了近期与青光眼眼压独立危险因素、视网膜神经节细胞死亡机制以及现代潜在治疗策略相关的研究。第一部分包括对青光眼血流变化、神经营养因子缺乏和凋亡失调研究结果的综述。
