Augoff K, Taboła R, Kula J, Gosk J, Rutowski R
Department of Traumatic Surgery and Hand Surgery, Medical University, Wrocław, Poland.
J Hand Surg Br. 2005 Dec;30(6):570-3. doi: 10.1016/j.jhsb.2005.06.008. Epub 2005 Aug 2.
The aim of this paper was to examine participation of the epidermal growth factor receptor (EGF-R) signal pathway in the pathogenesis of Dupuytren's disease. The study showed changes in the ratio of membrane EGF-R to its intracellular level during the different clinical stages of Dupuytren's contracture progression. Our observations of a high ratio of surface to intracellular EGF-R in the palmar aponeurosis of patients with second degree of Dupuytren's disease (Iselin's classification), which was significantly higher than this ratio in control palmar fascia (P=0.022), would suggest that EGF-R has a role in the involutional phase of the disease.
本文旨在研究表皮生长因子受体（EGF-R）信号通路在杜普伊特伦挛缩症发病机制中的作用。该研究显示，在杜普伊特伦挛缩进展的不同临床阶段，膜表皮生长因子受体与其细胞内水平的比例发生了变化。我们观察到，二度杜普伊特伦病（伊塞林分类法）患者掌腱膜中表面EGF-R与细胞内EGF-R的比例较高，显著高于对照掌腱膜中的该比例（P = 0.022），这表明EGF-R在该病的 involutional 阶段发挥作用。 （注：involutional 这个词在医学语境中较生僻，可能是“退化期”之类的意思，但仅根据提供文本，不能完全明确其准确含义）
