骨骼肌生成转录调控的潜在机制。
Mechanisms underlying the transcriptional regulation of skeletal myogenesis.
作者信息
Sartorelli Vittorio, Caretti Giuseppina
机构信息
Muscle Gene Expression Group, Laboratory of Muscle Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 50 South Drive, Room 1146, Bethesda, MD 20892-8024, USA.
出版信息
Curr Opin Genet Dev. 2005 Oct;15(5):528-35. doi: 10.1016/j.gde.2005.04.015.
Abstract
During skeletal myogenesis, chromatin-modifying enzymes are engaged at discrete genomic regions by transcription factors that recognize sequence-specific DNA motifs located at muscle gene regulatory regions. The composition of the chromatin-bound protein complexes and their temporally and spatially regulated recruitment influence gene expression. Recent findings are consistent with the concept that chromatin modifiers play an important role in regulating skeletal muscle gene expression and cellular differentiation.
摘要
在骨骼肌生成过程中，染色质修饰酶通过转录因子被募集到离散的基因组区域，这些转录因子识别位于肌肉基因调控区域的序列特异性DNA基序。染色质结合蛋白复合物的组成及其在时间和空间上的调控募集影响基因表达。最近的研究结果与染色质修饰剂在调节骨骼肌基因表达和细胞分化中起重要作用的概念一致。
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