Hostetler J S, Hanson L H, Stevens D A
Department of Medicine, Santa Clara Valley Medical Center, San Jose, California.
Antimicrob Agents Chemother. 1992 Feb;36(2):477-80. doi: 10.1128/AAC.36.2.477.
Concentrations of oral azoles in serum were compared in a single-dose pharmacologic study in mice. When hydroxypropyl-beta-cyclodextrin was used as a carrier and compared with a standard carrier, polyethylene glycol, drug concentrations determined by bioassay showed that the peak concentration and area under the concentration-time curve were greatly enhanced for itraconazole and saperconazole; moderately enhanced for ketoconazole; but negligibly affected for fluconazole, miconazole, and SCH 42427.
在一项针对小鼠的单剂量药理学研究中，对血清中口服唑类药物的浓度进行了比较。当使用羟丙基-β-环糊精作为载体并与标准载体聚乙二醇进行比较时，通过生物测定法测定的药物浓度显示，伊曲康唑和沙康唑的峰值浓度和浓度-时间曲线下面积大幅提高；酮康唑适度提高；但氟康唑、咪康唑和SCH 42427受影响可忽略不计。
