Chocholová L, Kolínová M
Physiol Bohemoslov. 1979;28(6):495-502.
In doses of 160 and 80 mg/kg, isatin (2,3-dioxoindoline) significantly reduced the total incidence of audiogenic epileptic seizures in rats highly sensitive to an acoustic epileptogenic stimulus. The number of severest forms of seizure (running, clonic convulsions) was higher than in the control tests, however. The acoustic epileptogenic stimuls was applied one hour after the i.p. injection of isatin. At that time some postural reflexes were still inhibited after 160 mg isatin/kg, while after smaller doses they were already normal again. One hour after administering isatin there were marked changes in the electroencephalogram, the chief ones being an increase in rhythmic episodic activity against a desynchronization background and a decrease in slow wave sleep activity.
剂量为160毫克/千克和80毫克/千克时，异吲哚酮（2,3-二氧代吲哚啉）可显著降低对听觉致痫刺激高度敏感的大鼠听源性癫痫发作的总发生率。然而，最严重的发作形式（奔跑、阵挛性惊厥）的数量高于对照试验。在腹腔注射异吲哚酮1小时后施加听觉致痫刺激。此时，160毫克异吲哚酮/千克给药后一些姿势反射仍受抑制，而较小剂量给药后姿势反射已恢复正常。给予异吲哚酮1小时后，脑电图有明显变化，主要变化是在去同步化背景下节律性发作活动增加以及慢波睡眠活动减少。
