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酵母的一般分泌途径中是否存在挽救途径?

Are there salvage routes within the general secretory pathway in yeast?

作者信息

Gozalbo D, Martínez J P, Sentandreu R

机构信息

Sección de Microbiología, Facultad de Farmacia, Universitat de València, Spain.

出版信息

Microbiologia. 1992 Apr;8(1):1-8.

PMID:1605916
Abstract

It is generally accepted that both extracellular protein secretion and plasma membrane expansion in yeast occur basically as in higher eukaryotic cells. In addition to the constitutive (default) secretory pathway, some specialized mammalian cells possess a regulated route which at present has not been detected in yeast. However, there is a body of experimental results suggesting that under certain circumstances export of integral plasma membrane and exocellular proteins may take place through alternative (salvage) pathways. The existence of these latter routes would enable the yeast cell to adapt more efficiently to distinct or adverse conditions requiring the secretion of discrete amounts of specific sets of proteins.

摘要

人们普遍认为,酵母细胞中的细胞外蛋白质分泌和质膜扩张基本上与高等真核细胞中的情况相同。除了组成型(默认)分泌途径外,一些特化的哺乳动物细胞拥有一种调节途径,目前在酵母中尚未检测到。然而,有大量实验结果表明,在某些情况下,整合质膜蛋白和细胞外蛋白的输出可能通过替代(挽救)途径进行。后一种途径的存在将使酵母细胞能够更有效地适应需要分泌不同数量特定蛋白质组的不同或不利条件。

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