内源性大麻素及其对癫痫的影响。
Endocannabinoids and their implications for epilepsy.
作者信息
Alger Bradley E
机构信息
Department of Physiology, University of Maryland School of Medicine, Baltimore 21201, USA.
出版信息
Epilepsy Curr. 2004 Sep-Oct;4(5):169-73. doi: 10.1111/j.1535-7597.2004.04501.x.
Abstract
This review covers the main features of a newly discovered intercellular signaling system in which endogenous ligands of the brain's cannabinoid receptors, or endocannabinoids, serve as retrograde messengers that enable a cell to control the strength of its own synaptic inputs. Endocannabinoids are released by bursts of action potentials, including events resembling interictal spikes, and probably by seizures as well. Activation of cannabinoid receptors has been implicated in neuroprotection against excitotoxicity and can help explain the anticonvulsant properties of cannabinoids that have been known since antiquity.
摘要
本综述涵盖了新发现的一种细胞间信号系统的主要特征，在该系统中，大脑大麻素受体的内源性配体，即内源性大麻素，充当逆行信使，使细胞能够控制自身突触输入的强度。内源性大麻素由动作电位爆发释放，包括类似发作间期棘波的事件，可能癫痫发作时也会释放。大麻素受体的激活与对抗兴奋性毒性的神经保护作用有关，这有助于解释自古以来就已知的大麻素的抗惊厥特性。
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Nat Rev Neurosci. 2003 Nov;4(11):873-84. doi: 10.1038/nrn1247.
2
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Science. 2003 Oct 3;302(5642):84-8. doi: 10.1126/science.1088208.
3
Long-term plasticity of endocannabinoid signaling induced by developmental febrile seizures.发育性热性惊厥诱导的内源性大麻素信号传导的长期可塑性。
Neuron. 2003 Aug 14;39(4):599-611. doi: 10.1016/s0896-6273(03)00499-9.
4
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