Bastos Victor Hugo, Machado Dionis, Cunha Marlo, Portella Claudio Elidio, Cagy Maurício, Furtado Vernon, Piedade Roberto, Ribeiro Pedro
Laboratório de Mapeamento Cerebral e Integração Sensório-Motora, Instituto de Psiquiatria, Brazil.
Arq Neuropsiquiatr. 2005 Jun;63(2B):443-51. doi: 10.1590/s0004-282x2005000300015. Epub 2005 Jul 25.
Neuromodulators change brain's neural circuitry. Bromazepam is often been used in the pharmacological treatment of anxiety disorders. Few papers links this anxiolytic to motor tasks. The purpose of this study was to examine motor and electrophysiological changes produced by administration of bromazepam in differents doses (3 and 6 mg). The sample consisted of 39 healthy individuals, of both sexes, between 20 and 30 years of age. The control (placebo) and experimental (bromazepam 3mg and bromazepam 6 mg) groups were submitted to a typewriting task, in a randomized, double-blind design. The results did not reveal differences on score and time of the attention test. In the comportamental analysis was noticed blocks as main effect to behavioral variables (time and mistakes in the task). Electrophysiological data showed significants interactions to: laterally/condition/moment; laterally/condition; laterally/moment; condition/moment; condition/site.
神经调节剂会改变大脑的神经回路。溴西泮常用于焦虑症的药物治疗。很少有论文将这种抗焦虑药与运动任务联系起来。本研究的目的是检查不同剂量(3毫克和6毫克)的溴西泮给药后产生的运动和电生理变化。样本包括39名年龄在20至30岁之间的健康男女个体。对照组(安慰剂)和实验组(3毫克溴西泮和6毫克溴西泮)采用随机双盲设计进行打字任务。结果未显示注意力测试的得分和时间存在差异。在行为分析中,发现组块是行为变量(任务时间和错误)的主要影响因素。电生理数据显示在以下方面存在显著交互作用:外侧/条件/时刻;外侧/条件;外侧/时刻;条件/时刻;条件/部位。