Dougherty T J, Pucci M J, Zawadzke L, Barrett J F
Bristol-Myers Squibb Pharmaceutical Research Institute, Department of Infectious Diseases - Microbiology, 5 Research Parkway, Wallingford, CT 06492, USA.
IDrugs. 2000 Aug;3(8):857-60.
Symposium sessions on genomics, surveillance, and pharmaceutical intervention opportunities were highlights of this annual ASM meeting. Two-component signal transduction was highlighted by both academic and industrial representatives, as was prokaryotic genomics. Recurring themes throughout the meeting were the contribution of efflux mechanisms to worldwide resistance, target modifications responsible for fluoroquinolone resistance, and the role of structural biology in the discovery and exploitation of bacterial targets.
关于基因组学、监测和药物干预机会的研讨会是本次美国微生物学会年度会议的亮点。双组分信号转导受到了学术和工业界代表的关注，原核生物基因组学也是如此。会议期间反复出现的主题包括外排机制对全球耐药性的影响、导致氟喹诺酮耐药性的靶点修饰，以及结构生物学在细菌靶点发现和开发中的作用。
