• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

鱼类中Groucho/Tle基因家族的重复成员。

Duplicated members of the Groucho/Tle gene family in fish.

作者信息

Aghaallaei Narges, Bajoghli Baubak, Walter Ingrid, Czerny Thomas

机构信息

Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria.

出版信息

Dev Dyn. 2005 Sep;234(1):143-50. doi: 10.1002/dvdy.20510.

DOI:10.1002/dvdy.20510
PMID:16059907
Abstract

The highly conserved Groucho/Tle gene family has widespread functions during embryonic development and in adults. For mammalians, four full-length Tle paralogues are known, whereas the whole spectrum of this gene family in fish species has not been analysed yet. Most detailed data exist for medaka, where 3 Tle genes have been described, Tle1, Tle3, and Tle4. We now isolated 3 additional Tle genes from the medaka genome. Sequence analysis identifies these genes as Tle2a, Tle2b, and Tle3b. Database searches of genomic sequences revealed an identical set of Tle paralogues being present in distantly related fish species, indicating duplicated Tle2 and Tle3 genes for the complete teleost lineage. Like the previously analysed medaka Tle genes, the three new genes show a broad expression pattern during embryogenesis. Nevertheless, a detailed comparison of all six Tle genes reveals critical differences in certain aspects of their expression pattern. In particular, we concentrated on the activity of Tle genes during ear development and found Tle2a and Tle2b expressed in this sensory organ.

摘要

高度保守的Groucho/Tle基因家族在胚胎发育和成年期具有广泛的功能。对于哺乳动物来说,已知有四个全长的Tle旁系同源物,而鱼类中该基因家族的全貌尚未进行分析。关于青鳉的详细数据最多,已描述了3个Tle基因,即Tle1、Tle3和Tle4。我们现在从青鳉基因组中分离出另外3个Tle基因。序列分析将这些基因鉴定为Tle2a、Tle2b和Tle3b。对基因组序列进行数据库搜索发现,在远缘鱼类物种中存在一组相同的Tle旁系同源物,这表明整个硬骨鱼谱系中存在Tle2和Tle3基因的重复。与之前分析的青鳉Tle基因一样,这三个新基因在胚胎发育过程中表现出广泛的表达模式。然而,对所有六个Tle基因进行详细比较后发现,它们在表达模式的某些方面存在关键差异。特别是,我们重点研究了Tle基因在耳朵发育过程中的活性,发现Tle2a和Tle2b在这个感觉器官中表达。

相似文献

1
Duplicated members of the Groucho/Tle gene family in fish.鱼类中Groucho/Tle基因家族的重复成员。
Dev Dyn. 2005 Sep;234(1):143-50. doi: 10.1002/dvdy.20510.
2
Evolution of the Groucho/Tle gene family: gene organization and duplication events.格罗乔/转导素样增强子(Groucho/Tle)基因家族的进化:基因组织与复制事件
Dev Genes Evol. 2007 Aug;217(8):613-8. doi: 10.1007/s00427-007-0167-y. Epub 2007 Jul 12.
3
Groucho corepressor proteins regulate otic vesicle outgrowth.
Dev Dyn. 2005 Jul;233(3):760-71. doi: 10.1002/dvdy.20398.
4
Expression of Groucho/TLE proteins during pancreas development.Groucho/TLE蛋白在胰腺发育过程中的表达。
BMC Dev Biol. 2008 Sep 8;8:81. doi: 10.1186/1471-213X-8-81.
5
Comparative analysis of her genes during fish somitogenesis suggests a mouse/chick-like mode of oscillation in medaka.在鱼类体节发生过程中对其基因进行的比较分析表明,青鳉中存在类似小鼠/鸡的振荡模式。
Dev Genes Evol. 2006 Jun;216(6):315-32. doi: 10.1007/s00427-006-0059-6. Epub 2006 Mar 17.
6
Five Nkx5 genes show differential expression patterns in anlagen of sensory organs in medaka: insight into the evolution of the gene family.
Dev Genes Evol. 2001 Jul;211(7):338-49. doi: 10.1007/s004270100162.
7
Identification of three duplicated Spin genes in medaka (Oryzias latipes).在青鳉(Oryzias latipes)中鉴定出三个重复的Spin基因。
Gene. 2005 May 9;350(2):99-106. doi: 10.1016/j.gene.2005.02.002. Epub 2005 Mar 21.
8
Six3 and Six6 activity is modulated by members of the groucho family.Six3和Six6的活性受毛状体家族成员的调节。
Development. 2003 Jan;130(1):185-95. doi: 10.1242/dev.00185.
9
Characterization of hey bHLH genes in teleost fish.硬骨鱼中hey bHLH基因的特征分析
Dev Genes Evol. 2003 Nov;213(11):541-53. doi: 10.1007/s00427-003-0360-6. Epub 2003 Oct 31.
10
The function of tcf3 in medaka embryos: efficient knockdown with pePNAs.tcf3 在胚胎中的功能:pePNAs 的高效敲低。
BMC Biotechnol. 2018 Jan 9;18(1):1. doi: 10.1186/s12896-017-0411-0.

引用本文的文献

1
Altered thymic niche synergistically drives the massive proliferation of malignant thymocytes.改变的胸腺生态位协同驱动恶性胸腺细胞的大量增殖。
Elife. 2025 Sep 16;13:RP101137. doi: 10.7554/eLife.101137.
2
Role of and in Regulating Metamorphosis and Ovary Development in (Stål).和在调控 (Stål)变态和卵巢发育中的作用。
Int J Mol Sci. 2022 Jan 21;23(3):1197. doi: 10.3390/ijms23031197.
3
Unravelling paralogous gene expression dynamics during three-spined stickleback embryogenesis.揭示三刺鱼胚胎发生过程中基因表达的动态变化。
Sci Rep. 2019 Mar 6;9(1):3752. doi: 10.1038/s41598-019-40127-2.
4
The function of tcf3 in medaka embryos: efficient knockdown with pePNAs.tcf3 在胚胎中的功能:pePNAs 的高效敲低。
BMC Biotechnol. 2018 Jan 9;18(1):1. doi: 10.1186/s12896-017-0411-0.
5
Identification, visualization and clonal analysis of intestinal stem cells in fish.鱼类肠道干细胞的鉴定、可视化及克隆分析
Development. 2016 Oct 1;143(19):3470-3480. doi: 10.1242/dev.134098. Epub 2016 Aug 30.
6
Side chain modified peptide nucleic acids (PNA) for knock-down of six3 in medaka embryos.侧链修饰的肽核酸(PNA)用于 knockdown 斑马鱼胚胎中的 six3。
BMC Biotechnol. 2012 Aug 17;12:50. doi: 10.1186/1472-6750-12-50.
7
AES/GRG5: more than just a dominant-negative TLE/GRG family member.AES/GRG5:不仅仅是一个显性负性的 TLE/GRG 家族成员。
Dev Dyn. 2010 Nov;239(11):2795-805. doi: 10.1002/dvdy.22439.
8
The germ cell nuclear proteins hnRNP G-T and RBMY activate a testis-specific exon.核蛋白 hnRNP G-T 和 RBMY 激活睾丸特异性外显子。
PLoS Genet. 2009 Nov;5(11):e1000707. doi: 10.1371/journal.pgen.1000707. Epub 2009 Nov 6.
9
Induction of otic structures by canonical Wnt signalling in medaka.诱导耳结构的经典 Wnt 信号在斑马鱼中。
Dev Genes Evol. 2009 Aug;219(8):391-8. doi: 10.1007/s00427-009-0302-z. Epub 2009 Sep 16.
10
Rapid identification of PAX2/5/8 direct downstream targets in the otic vesicle by combinatorial use of bioinformatics tools.通过组合使用生物信息学工具,快速鉴定耳泡中 PAX2/5/8 的直接下游靶标。
Genome Biol. 2008 Oct 1;9(10):R145. doi: 10.1186/gb-2008-9-10-r145.