Jadeszko Iwona, Porowski Tadeusz, Zoch-Zwierz Walentyna M, Wasilewska Anna M, Hackiewicz Lech
Z I Kliniki Chorób Dzieci Akademii Medycznej w Białymstoku.
Wiad Lek. 2005;58 Suppl 1:20-4.
Oxalate crystals are the main component of renal stones and oxalate urolithiasis is the most common type both in adults and children. The aim of the work was the assessment of oxalate concentration in plasma and urine of children with renal stones.
The examined group (I) consisted of 29 children (12.0 +/- 3.87 years) with confirmed stones in caliceal-pelvic system. The control group (C) was composed of 30 healthy children.
The oxalate concentration in plasma and urine was measured using an enzymatic method after 3-4 days of hypooxalate diet. Children with congenital abnormalities of urinary tract were excluded. We found 1-5 stones, 0.35-1.5 in diameter.
In I group mean plasma oxalate concentration (4.89 +/- 1.58 micromol/l) was higher than in control group (p<0,05). However urinary oxalate concentration exceeded 95 percentile of those obtained in healthy group only in 16 (55%) children, mainly with II and III degree of urolithiasis. In children with urolithiasis we also found hypercalciuria with normal serum calcium concentration. No correlation between plasma and urinary oxalate concentration was found.
草酸盐晶体是肾结石的主要成分，草酸盐尿路结石在成人和儿童中都是最常见的类型。这项工作的目的是评估肾结石患儿血浆和尿液中的草酸盐浓度。
研究组（I）由29名（12.0±3.87岁）肾盂系统确诊有结石的儿童组成。对照组（C）由30名健康儿童组成。
在低草酸盐饮食3 - 4天后，采用酶法测量血浆和尿液中的草酸盐浓度。排除患有先天性尿路异常的儿童。我们发现1 - 5颗结石，直径0.35 - 1.5厘米。
I组血浆草酸盐平均浓度（4.89±1.58微摩尔/升）高于对照组（p<0.05）。然而，仅16名（55%）儿童的尿草酸盐浓度超过了健康组的第95百分位数，主要是患有II度和III度尿路结石的儿童。在患有尿路结石的儿童中我们还发现了血清钙浓度正常的高钙尿症。未发现血浆和尿草酸盐浓度之间存在相关性。
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