Hoppe B, Jahnen A, Bach D, Hesse A
Department of Urology, University of Bonn, Germany.
J Urol. 1997 Aug;158(2):557-9.
A number of factors influence the development of renal calculi, the most essential of which is the supersaturation of urine with lithogenic substances. Calcium oxalate stones occur most frequently in adult and pediatric patients with urolithiasis. Therefore, we established normal age and sex related data for urinary calcium oxalate saturation in infancy and childhood to allow a more specific prediction of the risk of (recurrent) stone disease.
We collected 24-hour urine samples from 473 healthy infants and children without a history of renal stones. Urinary lithogenic and stone inhibitory substances were measured, and the urinary calcium oxalate saturation was calculated using a computer program.
Mean urinary calcium oxalate saturation was always higher in boys than in girls, which was significant in infancy (5.22 versus 2.03, p < 0.05) and at ages 7 to 9 years (8.84 versus 5.47, p < 0.05). The saturation first increased (p < 0.05) until age 7 to 9 years in boys and girls, and remained at high levels at ages 10 to 12 years (7.03 versus 5.49, p < 0.05 compared to infancy). Calcium oxalate saturation then decreased until adolescence when values were comparable to those of infancy (5.29 versus 3.35).
We recommend calculating urinary calcium oxalate saturation for diagnostic purposes as well as for therapy control. Normal age and sex related values must be considered.
多种因素影响肾结石的形成，其中最关键的是尿液中致石物质的过饱和。草酸钙结石在成人和儿童尿路结石患者中最为常见。因此，我们建立了婴儿期和儿童期尿草酸钙饱和度的正常年龄和性别相关数据，以便更准确地预测（复发性）结石病的风险。
我们收集了473名无肾结石病史的健康婴儿和儿童的24小时尿液样本。测量了尿中致石和抑石物质，并使用计算机程序计算尿草酸钙饱和度。
男孩的平均尿草酸钙饱和度始终高于女孩，在婴儿期（5.22对2.03，p<0.05）和7至9岁时（8.84对5.47，p<0.05）差异显著。饱和度在男孩和女孩中首先升高（p<0.05），直到7至9岁，在10至12岁时保持在较高水平（7.03对5.49，与婴儿期相比p<0.05）。然后草酸钙饱和度下降，直到青春期，此时的值与婴儿期相当（5.29对3.35）。
我们建议计算尿草酸钙饱和度用于诊断目的以及治疗控制。必须考虑正常的年龄和性别相关值。
