Visvardis G, Griveas Ioannis, Fleva A, Giannakou A, Papadopoulou D, Mitsopoulos E, Kyriklidou P, Manou E, Ginikopoulou E, Meimaridou D, Pavlitou K, Sakellariou G
Nephrology Department, Papageorgiou General Hospital, Thessaloniki, Greece.
Ren Fail. 2005;27(4):429-34.
The objective of this study was to evaluate the diagnostic value of serum procalcitonin (PCT) in hemodialysis (HD) patients and its correlation to other traditional inflammatory markers.
We measured plasma PCT levels in 120 patients on maintenance HD. PCT levels were compared with C-reactive protein (CRP), interleukin-6 (IL-6), prealbumin, and albumin. We also examined the above parameters subgroups, especially in diabetics and the elderly. Relations between parameters were studied by Spearman's correlation.
PCT concentrations were higher than the upper normal limit of 0.5 ng/ mL in 38% of the patients. All patients with increased CRP had PCT concentrations higher than the upper normal limit. Plasma CRP concentrations were positively correlated to IL-6 (r = 0.304). Prealbumin was negatively correlated with CRP (r = 0.259) and with IL-6 (r = 0.388).
The combination of elevated IL-6 and CRP levels was associated with an altered nutritional status. The concomitant elevations in PCT, CRP, and IL-6 could be more sensitive in the evaluation of inflammation.
本研究的目的是评估血清降钙素原（PCT）在血液透析（HD）患者中的诊断价值及其与其他传统炎症标志物的相关性。
我们检测了120例维持性血液透析患者的血浆PCT水平。将PCT水平与C反应蛋白（CRP）、白细胞介素-6（IL-6）、前白蛋白和白蛋白进行比较。我们还检查了上述参数的亚组，特别是糖尿病患者和老年患者亚组。通过Spearman相关性分析研究参数之间的关系。
38%的患者PCT浓度高于正常上限0.5 ng/mL。所有CRP升高的患者PCT浓度均高于正常上限。血浆CRP浓度与IL-6呈正相关（r = 0.304）。前白蛋白与CRP呈负相关（r = 0.259），与IL-6呈负相关（r = 0.388）。
IL-6和CRP水平升高与营养状况改变有关。PCT、CRP和IL-6同时升高在评估炎症方面可能更敏感。
