Schaap Laura A, Pluijm Saskia M F, Smit Jan H, van Schoor Natasja M, Visser Marjolein, Gooren Louis J G, Lips Paul
Institute for Research in Extramural Medicine (EMGO Institute), VU University Medical Center, Amsterdam, the Netherlands.
Clin Endocrinol (Oxf). 2005 Aug;63(2):152-60. doi: 10.1111/j.1365-2265.2005.02315.x.
The objective of this study was to examine whether low levels of oestradiol and testosterone are associated with impaired mobility, low muscle strength and the incidence of falls in a population-based sample of older men and women.
Cross-sectional population-based study, based on data of the Longitudinal Ageing Study Amsterdam (LASA), including 623 men and 663 women, aged 65-88 years.
Serum levels of oestradiol, testosterone, albumin and sex hormone-binding globulin (SHBG) were measured. Physical performance, functional limitations and muscle strength were assessed, and a follow-up on falls was performed prospectively within 3 years.
After adjustment for age, level of education, alcohol use, physical activity, chronic disease and body mass index (BMI), men in the highest quartile of the oestradiol/SHBG ratio had significantly higher physical performance scores than men in the lowest quartile (beta = 0.103). Serum levels of total testosterone were positively associated with muscle strength (beta = 0.085). Calculated bioavailable testosterone levels were positively associated with physical performance and muscle strength (beta = 0.128 and 0.109 respectively). No associations of oestradiol levels with mobility were seen in women. Levels of oestradiol and testosterone were not associated with falls.
It can be concluded that low levels of sex hormones were associated with impaired mobility and low muscle strength in men, but not in women. Levels of sex hormones were not associated with the incidence of falls neither in men, nor in women.
本研究的目的是在一个基于人群的老年男性和女性样本中，检验低水平的雌二醇和睾酮是否与行动能力受损、肌肉力量低下以及跌倒发生率相关。
基于阿姆斯特丹纵向衰老研究（LASA）数据的横断面人群研究，包括623名男性和663名女性，年龄在65 - 88岁之间。
测定血清雌二醇、睾酮、白蛋白和性激素结合球蛋白（SHBG）水平。评估身体机能、功能受限情况和肌肉力量，并对3年内的跌倒情况进行前瞻性随访。
在对年龄、教育水平、饮酒情况、身体活动、慢性病和体重指数（BMI）进行调整后，雌二醇/SHBG比值处于最高四分位数的男性，其身体机能得分显著高于最低四分位数的男性（β = 0.103）。总睾酮血清水平与肌肉力量呈正相关（β = 0.085）。计算得出的生物可利用睾酮水平与身体机能和肌肉力量呈正相关（分别为β = 0.128和0.109）。在女性中未发现雌二醇水平与行动能力之间存在关联。雌二醇和睾酮水平与跌倒无关。
可以得出结论，低水平性激素与男性行动能力受损和肌肉力量低下相关，但与女性无关。性激素水平在男性和女性中均与跌倒发生率无关。
