社区居住老年人的握力、步速和认知功能轨迹：一项前瞻性研究。
Grip strength, gait speed, and trajectories of cognitive function in community-dwelling older adults: A prospective study.
作者信息
Wu Zimu, Woods Robyn L, Chong Trevor T-J, Orchard Suzanne G, Shah Raj C, Wolfe Rory, Storey Elsdon, Sheets Kerry M, Murray Anne M, McNeil John J, Ryan Joanne
机构信息
School of Public Health and Preventive Medicine Monash University Melbourne Victoria Australia.
Turner Institute for Brain and Mental Health Monash University Melbourne Victoria Australia.
出版信息
Alzheimers Dement (Amst). 2023 Feb 14;15(1):e12388. doi: 10.1002/dad2.12388. eCollection 2023 Jan-Mar.
INTRODUCTION
This study investigated whether grip strength and gait speed predict cognitive aging trajectories and examined potential sex-specific associations.
METHODS
Community-dwelling older adults ( = 19,114) were followed for up to 7 years, with regular assessment of global function, episodic memory, psychomotor speed, and executive function. Group-based multi-trajectory modeling identified joint cognitive trajectories. Multinomial logistic regression examined the association of grip strength and gait speed at baseline with cognitive trajectories.
RESULTS
High performers (14.3%, = 2298) and low performers (4.0%, = 642) were compared to the average performers (21.8%, = 3492). Grip strength and gait speed were positively associated with high performance and negatively with low performance (-values < 0.01). The association between grip strength and high performance was stronger in women (interaction < 0.001), while gait speed was a stronger predictor of low performance in men (interaction < 0.05).
DISCUSSION
Grip strength and gait speed are associated with cognitive trajectories in older age, but with sex differences.
HIGHLIGHTS
There is inter-individual variability in late-life cognitive trajectories.Grip strength and gait speed predicted cognitive trajectories in older age.However, sex-specific associations were identified.In women, grip strength strongly predicted high, compared to average, trajectory.In men, gait speed was a stronger predictor of low cognitive performance trajectory.
引言
本研究调查了握力和步速是否能预测认知衰老轨迹，并检验了潜在的性别特异性关联。
方法
对19114名社区居住的老年人进行了长达7年的随访，定期评估整体功能、情景记忆、精神运动速度和执行功能。基于群体的多轨迹建模确定了联合认知轨迹。多项逻辑回归分析了基线时握力和步速与认知轨迹的关联。
结果
将表现优秀者（14.3%，n = 2298）和表现较差者（4.0%，n = 642）与表现中等者（21.8%，n = 3492）进行比较。握力和步速与高表现呈正相关，与低表现呈负相关（p值<0.01）。握力与高表现之间的关联在女性中更强（交互作用p<0.001），而步速是男性低表现的更强预测因素（交互作用p<0.05）。
讨论
握力和步速与老年人的认知轨迹相关，但存在性别差异。
要点
晚年认知轨迹存在个体间差异。握力和步速可预测老年人的认知轨迹。然而，发现了性别特异性关联。在女性中，与平均轨迹相比，握力强烈预测高轨迹。在男性中，步速是低认知表现轨迹的更强预测因素。
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