巴西副球孢子菌致病真菌的功能基因组

Functional genome of the human pathogenic fungus Paracoccidioides brasiliensis.

作者信息

Felipe Maria Sueli S, Torres Fernando A G, Maranhão Andrea Q, Silva-Pereira Ildinete, Poças-Fonseca Marcio J, Campos Elida G, Moraes Lídia M P, Arraes Fabrício B M, Carvalho Maria José A, Andrade Rosângela V, Nicola André M, Teixeira Marcus M, Jesuíno Rosália S A, Pereira Maristela, Soares Célia M A, Brígido Marcelo M

机构信息

Departamento de Biologia Celular, Laboratório de Biologia Molecular, Instituto de Biologia, Universidade de Brasília.

出版信息

FEMS Immunol Med Microbiol. 2005 Sep 1;45(3):369-81. doi: 10.1016/j.femsim.2005.05.013.

DOI:10.1016/j.femsim.2005.05.013

PMID:16061364

Abstract

Paracoccidioides brasiliensis is a dimorphic and thermo-regulated fungus which is the causative agent of paracoccidioidomycosis, an endemic disease widespread in Latin America. Pathogenicity is assumed to be a consequence of the cellular differentiation process that this fungus undergoes from mycelium to yeast cells during human infection. In an effort to elucidate the molecular mechanisms involved in this process a network of Brazilian laboratories carried out a transcriptome project for both cell types. This review focuses on the data analysis yielding a comprehensive view of the fungal metabolism and the molecular adaptations during dimorphism in P. brasiliensis from analysis of 6022 groups, related to expressed genes, which were generated from both mycelium and yeast phases.

摘要

巴西副球孢子菌是一种双态且受温度调节的真菌，是副球孢子菌病的病原体，这是一种在拉丁美洲广泛流行的地方病。致病性被认为是这种真菌在人类感染期间从菌丝体到酵母细胞所经历的细胞分化过程的结果。为了阐明这一过程中涉及的分子机制，巴西的一个实验室网络对这两种细胞类型进行了转录组项目。本综述重点关注数据分析，通过对来自菌丝体和酵母阶段的6022个与表达基因相关的组进行分析，全面了解巴西副球孢子菌双态性过程中的真菌代谢和分子适应性。