[肝脾及肾脏念珠菌病并发急性髓细胞白血病。1例接受伏立康唑和卡泊芬净治疗的病例]

[Hepatosplenic and kidneys candidasis complicating an acute myeloblastic leukemia. A case treated with voriconazole and caspofungin].

作者信息

Elouennass M, Doghmi K, Fagot T, Soler C, Mac Nab C, Foissaud V, De Revel T, Hervé V

机构信息

Service de biologie médicale, hôpital d'instruction des armées Percy, Clamart.

出版信息

Ann Biol Clin (Paris). 2005 Jul-Aug;63(4):423-7.

PMID:16061441

Abstract

We report the observation of hepato-splenic and kidneys candidiasis complicating the chemotherapy of a myeloblastic leukemia (LAM5b). Following the lack of effectiveness of a first line treatement, using amphotericine B liposomale and 5-fluorocytosine, implementation of an association of new molecules, a triazole of second generation (voriconazole) and an echinocandine (caspofungine) has allowed a successful result.

摘要

我们报告了1例髓母细胞白血病（LAM5b）化疗后并发肝脾及肾脏念珠菌病的观察结果。在一线治疗（使用两性霉素B脂质体和5-氟胞嘧啶）无效后，采用新分子联合治疗，即第二代三唑类药物（伏立康唑）和棘白菌素类药物（卡泊芬净），取得了成功。