Duvernoy Claire S, Bates Eric R
Division of Cardiovascular Medicine and Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
J Intensive Care Med. 2005 Jul-Aug;20(4):188-98. doi: 10.1177/0885066605276802.
Cardiogenic shock is the leading cause of death among patients hospitalized with acute myocardial infarction. It is defined as tissue hypoperfusion resulting from ventricular pump failure in the presence of adequate intravascular volume. Rapid assessment and triage of patients presenting in cardiogenic shock followed by appropriate institution of supportive therapies including vasopressor and inotropic agents, mechanical ventilatory support, and intra-aortic balloon pump counterpulsation are critical for effective management of these patients. However, emergency percutaneous coronary intervention or coronary artery bypass graft surgery is required to decrease mortality rates. Novel approaches, including inhibition of nitric oxide synthase and new mechanical support devices, may further decrease mortality rates, which remain high despite reperfusion therapy.
心源性休克是急性心肌梗死住院患者死亡的主要原因。它被定义为在血管内容量充足的情况下，由于心室泵功能衰竭导致的组织灌注不足。对心源性休克患者进行快速评估和分诊，随后适当采用包括血管升压药和正性肌力药、机械通气支持以及主动脉内球囊反搏等支持治疗措施，对于有效管理这些患者至关重要。然而，需要进行紧急经皮冠状动脉介入治疗或冠状动脉旁路移植手术以降低死亡率。包括抑制一氧化氮合酶和新型机械支持装置在内的新方法，可能会进一步降低死亡率，尽管进行了再灌注治疗，但死亡率仍然很高。
