HIV-1共受体使用情况的测定
Determination of co-receptor usage of HIV-1.
作者信息
Schuitemaker Hanneke, Kootstra Neeltje A
机构信息
Department of Clinical Viro-Immunology Sanquin Research at CLB, Academical Medical Center, Amsterdam, The Netherlands.
出版信息
Methods Mol Biol. 2005;304:327-32. doi: 10.1385/1-59259-907-9:327.
In addition to CD4, HIV-1 uses chemokine receptors for entry in their target cells. The most important chemokine receptors in this respect are beta-chemokine receptor 5 (CCR5) and alpha-chemokine receptor 4 (CXCR4). Coreceptor usage is an important feature of the biological phenotype of HIV-1 variants. In this chapter, methods are described to determine the co-receptor usage of HIV-1 variants.
除CD4外，HIV-1还利用趋化因子受体进入其靶细胞。在这方面最重要的趋化因子受体是β趋化因子受体5（CCR5）和α趋化因子受体4（CXCR4）。辅助受体的使用是HIV-1变体生物学表型的一个重要特征。在本章中，将描述确定HIV-1变体辅助受体使用情况的方法。
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