Dahiya K, Madan S, Hooda R, Sangwan K, Khosla A H
Department of Obstetrics and Gynaecology, Pt. B.D. Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.
Indian J Med Sci. 2005 Jul;59(7):301-6.
Unsafe abortion is a major cause of mortality among women in India accounting for 12% of all maternal deaths. In developing countries, annually, up to 200,000 women die of complications after illegal abortion. Medical abortion is potentially a simple and a safe method for use in developing countries. We conducted a prospective controlled trial to compare the efficacy of low-lose mifepristone and methotrexate for medical abortion.
To find out the efficacy of low-dose mifepristone and methotrexate for inducing abortion.
In this prospective clinical study, 100 women opted for a medical method of abortion. Out of these, 50 patients were given 50 mg/m2 of methotrexate intramuscularly followed by 800 micro gm of intravaginal misoprostol, and 50 patients were given 200 mg of mifepristone orally followed by 800 micro gm of intravaginal misoprostol.
Complete abortion was the principal outcome measure. Secondary outcome measures were side effects and acceptability data.
The rate of expulsion by first week after initiation of treatment was 58% in methotrexate and 98% in mifepristone group (P <0.001).
Low-dose mifepristone and intravaginal misoprostol is safe, effective, and well tolerated as compared to methotrexate and misoprostol.
不安全堕胎是印度女性死亡的主要原因，占所有孕产妇死亡的12%。在发展中国家，每年有多达20万名妇女死于非法堕胎后的并发症。药物流产在发展中国家可能是一种简单且安全的方法。我们进行了一项前瞻性对照试验，以比较低剂量米非司酮和甲氨蝶呤用于药物流产的疗效。
了解低剂量米非司酮和甲氨蝶呤诱导流产的疗效。
在这项前瞻性临床研究中，100名妇女选择了药物流产方法。其中，50名患者肌肉注射50mg/m²甲氨蝶呤，随后阴道给予800μg米索前列醇；50名患者口服200mg米非司酮，随后阴道给予800μg米索前列醇。
完全流产是主要观察指标。次要观察指标是副作用和可接受性数据。
治疗开始后第一周，甲氨蝶呤组的排出率为58%，米非司酮组为98%（P<0.001）。
与甲氨蝶呤和米索前列醇相比，低剂量米非司酮和阴道用米索前列醇安全、有效且耐受性良好。
