Newlin Heather E, Morris Christopher G, Amdur Robert J, Mendenhall William M
Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, Florida, USA.
Am J Clin Oncol. 2005 Aug;28(4):399-402. doi: 10.1097/01.coc.0000144853.76112.3d.
The purpose of this article is to report our experience with neurotropic melanoma, a rare malignancy that sometimes produces neurologic symptoms because of a direct extension of the primary tumor.
We report 3 consecutive patients with neurotropic melanoma of the head and neck who presented with clinical perineural invasion.
Two patients had incompletely resectable tumors and were treated with definitive radiotherapy (RT), and 1 patient received surgery and postoperative RT. One patient experienced recurrence in a regional lymph node 30 months after RT and underwent salvage surgery; he is disease-free at 45 months after initial treatment. The remaining 2 patients are disease-free 34 months and 14 months after treatment.
Radiotherapy alone or combined with surgery may provide relatively long-term local control in patients who have neurotropic melanoma with clinical perineural invasion.
本文旨在报告我们对嗜神经性黑色素瘤的治疗经验，这是一种罕见的恶性肿瘤，有时会因原发性肿瘤的直接蔓延而产生神经系统症状。
我们报告了3例连续的头颈部嗜神经性黑色素瘤患者，他们均表现出临床神经周围侵犯。
2例患者的肿瘤无法完全切除，接受了根治性放疗（RT），1例患者接受了手术及术后放疗。1例患者在放疗后30个月出现区域淋巴结复发并接受了挽救性手术；在初始治疗后45个月时无疾病迹象。其余2例患者在治疗后34个月和14个月时无疾病迹象。
对于有临床神经周围侵犯的嗜神经性黑色素瘤患者，单独放疗或放疗联合手术可能提供相对长期的局部控制。
