Zesiewicz Theresa A, Sanchez-Ramos Juan, Sullivan Kelly L, Hauser Robert A
Parkinson's Disease and Movement Disorders Center, NPF Centers of Experience, Department of Neurology, University of South Florida Tampa, Florida 33612, USA.
Clin Neuropharmacol. 2005 Jul-Aug;28(4):188-90. doi: 10.1097/01.wnf.0000169732.00690.32.
The authors present a man with Huntington disease who was treated with levetiracetam (Keppra) in an effort to reduce chorea. Chorea was markedly reduced, but the patient developed parkinsonism and lethargy after 6 weeks of treatment. Symptoms consisted of resting tremor, rigidity, increased dystonia, and gait difficulty. Side effects from levetiracetam resolved completely within 7 days of levetiracetam discontinuation, and chorea returned to baseline.
作者报告了一名患有亨廷顿病的男性患者，使用左乙拉西坦（开浦兰）进行治疗以减轻舞蹈症。舞蹈症明显减轻，但治疗6周后患者出现帕金森综合征和嗜睡。症状包括静止性震颤、强直、肌张力障碍加重和步态困难。左乙拉西坦停药7天内，其副作用完全消失，舞蹈症恢复至基线水平。
