Hoffmann E, Dorwarth U, Pulter R, Gokel M, Steinbeck G
Medizinische Klinik I, Ludwig-Maximilians-Universität München.
Biomed Tech (Berl). 1992 Apr;37(4):62-8. doi: 10.1515/bmte.1992.37.4.62.
Radiofrequency catheter ablation has been shown to be an effective form of treatment of accessory pathways in patients with WPW-syndrome and other supraventricular tachycardias. However, the biophysical parameters so far used in vivo neither correlated with the size of the myocardial lesion nor did they provide any information about contact of the electrode with the myocardial wall. In this study, 104 radiofrequency energy applications were performed on excised pig myocardium in circulating heparinized pig blood, and in blood alone, and root mean square (rms) voltage, current and phase angle were measured using a specially developed device. The calculated effective power and output power differed by only 2-7% measured at the point of maximum current during coagulation. A progressive drop in current following a rise in impedance led to a phase shift of more than 80 degrees with a decrease in effective power to 17% of the output power. Hence, apparent output power was mainly ineffective power. The time-dependent variations of phase angle, impedance and current were found to be useful for distinguishing between the coagulated media. These results show that physical parameters measured during radio-frequency catheter ablation may help to monitor electrode position in the clinical situation and reduce the number of ineffective energy applications.
射频导管消融术已被证明是治疗预激综合征(WPW 综合征)和其他室上性心动过速患者旁路的有效治疗方式。然而,目前体内使用的生物物理参数既与心肌损伤的大小无关,也未提供任何有关电极与心肌壁接触的信息。在本研究中,在循环肝素化猪血以及仅在血液中对切除的猪心肌进行了 104 次射频能量施加,并使用专门开发的设备测量了均方根(rms)电压、电流和相角。在凝血过程中,在最大电流点测量时,计算出的有效功率和输出功率仅相差 2 - 7%。随着阻抗升高电流逐渐下降,导致相移超过 80 度,有效功率降至输出功率的 17%。因此,表观输出功率主要是无效功率。发现相角、阻抗和电流随时间的变化有助于区分凝固介质。这些结果表明,在射频导管消融过程中测量的物理参数可能有助于在临床情况下监测电极位置并减少无效能量施加的次数。