Murphy C P, Harden E A, Thompson J M
Bone Marrow Transplant Service, Humana Hospital University of Louisville, KY 40202.
Ann Pharmacother. 1992 Jan;26(1):30-1. doi: 10.1177/106002809202600107.
Two patients without prior histories of neurologic disorders experienced generalized seizures while receiving high-dose busulfan (total dose 16 mg/kg) as part of a preparative regimen for allogeneic bone marrow transplantation. A review of the literature revealed 14 similar occurrences. Maintenance of therapeutic blood concentrations of phenytoin in subsequent patients at our institution has resulted in no further patients experiencing generalized seizures. Prophylactic anticonvulsant therapy should be considered in patients receiving high doses of busulfan.
两名既往无神经疾病史的患者在接受大剂量白消安（总剂量16mg/kg）作为异基因骨髓移植预处理方案的一部分时发生了全身性癫痫发作。文献回顾发现了14起类似事件。在我们机构，后续患者维持苯妥英钠的治疗血药浓度后，没有更多患者发生全身性癫痫发作。接受大剂量白消安治疗的患者应考虑预防性抗惊厥治疗。
