Larsson B, Vaara I
Department of Pediatrics Central Hospital, Växjo, Sweden.
Acta Paediatr. 1992 Apr;81(4):315-8. doi: 10.1111/j.1651-2227.1992.tb12233.x.
An inquiry was distributed to the parents of 1052 seven-year-old school beginners, concerning three issues, i.e. a known family history of myocardial infarction, angina pectoris before the age of 55 years and hyperlipidemia. A total of 147 children with a known family history were included in the study and compared with 148 classmates as control subjects. The proband children were subgrouped according to heredity factors and subjected to multivariate analysis at the 5% significance level for serum cholesterol fractions and triglycerides vs the control group. Statistically significant increased levels of total cholesterol and low density lipoprotein cholesterol, as well as an increased low density lipoprotein cholesterol and high density lipoprotein cholesterol ratio were found for all groups with hereditary for hyperlipidemia (p less than 0.001). However, no statistically significant difference was observed in the groups with heredity for myocardial infarction or angina pectoris exclusively. Also, there was no difference in any of the risk groups for high density lipoprotein cholesterol and triglycerides. The serum cholesterol levels in the present study were, to our knowledge, higher than those found elsewhere, except for Finland.
我们向1052名7岁入学儿童的家长发放了一份调查问卷，涉及三个问题，即已知的心肌梗死家族史、55岁之前的心绞痛家族史和高脂血症家族史。共有147名有已知家族史的儿童被纳入研究，并与148名同学作为对照对象进行比较。先证者儿童根据遗传因素进行分组，并在5%显著性水平下对血清胆固醇组分和甘油三酯与对照组进行多变量分析。在所有有高脂血症遗传史的组中，均发现总胆固醇和低密度脂蛋白胆固醇水平有统计学意义的升高，以及低密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值升高（p小于0.001）。然而，在仅有心肌梗死或心绞痛遗传史的组中未观察到统计学意义的差异。此外，在任何风险组中，高密度脂蛋白胆固醇和甘油三酯也没有差异。据我们所知，本研究中的血清胆固醇水平高于其他地方发现的水平，但芬兰除外。
