Sawyer J R, Thomas E L, Roloson G J, Chadduck W M, Boop F A
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock.
Cancer Genet Cytogenet. 1992 Jun;60(2):152-7. doi: 10.1016/0165-4608(92)90008-v.
Telomeric associations observed in a recurrent untreated pleomorphic xanthoastrocytoma were apparently the primary cytogenetic events that evolved by fusion and breakage events, resulting in subclones with ring chromosomes. The telomeric fusions between chromosomes 15pter and 20qter, and between an extra copy of the long arm of chromosome 1 and chromosome 22qter, evolved in a stepwise fashion to ring chromosomes 20 and 22. The findings in this tumor demonstrate that telomeric association is one mechanism that can initiate chromosome instability by generating subclones with unstable chromosome intermediates and result in ring chromosomes and subsequent chromosome loss.
在一例复发的未经治疗的多形性黄色星形细胞瘤中观察到的端粒联合显然是由融合和断裂事件演变而来的主要细胞遗传学事件，导致了带有环状染色体的亚克隆。15号染色体短臂末端与20号染色体长臂末端之间以及1号染色体长臂额外拷贝与22号染色体长臂末端之间的端粒融合以逐步方式演变为20号和22号环状染色体。该肿瘤中的发现表明，端粒联合是一种可通过产生具有不稳定染色体中间体的亚克隆来引发染色体不稳定并导致环状染色体及随后染色体丢失的机制。
