Cristina M L, Lehy T
Virchows Arch A Pathol Anat Histol. 1979 Jun 29;382(3):283-91. doi: 10.1007/BF00430404.
In endocrine cells of the colon of adults, children and fetuses, exocytotic granule release without any specific stimulation is reported. Omega-invaginations are observed on both the lateral and basal surfaces of all types of colonic endocrine cells. Several explanations for the phenomenon are suggested: 1) emiocytosis is probably more frequent in the colon than in the proximal gut, this allows its observation without requiring an exogenous stimulus, 2) since most of the exocytotic figures are from anaesthetized subjects it is also assumed that contraction of the muscular layer induced by anaesthetics and the resulting increase in intraluminal pressure were the possible causes of granule release, 3) in non-anaesthetized subjects release may have taken place in response to a normal endogenous physiological stimulus, or to the dilation of colon during colonoscopy. Certain figures on lateral surfaces between endocrine and adjacent cells i.e., bulges of parallel plasma membranes surrounding a secretory granule, were observed. Their significance is unknown.
据报道，在成人、儿童和胎儿结肠的内分泌细胞中，会出现无任何特定刺激的胞吐颗粒释放。在所有类型的结肠内分泌细胞的侧面和基底面均观察到ω-内陷。针对该现象提出了几种解释：1）胞吐作用在结肠中可能比在近端肠道中更频繁，这使得无需外源性刺激就能观察到它；2）由于大多数胞吐图像来自麻醉的受试者，因此还假定麻醉剂引起的肌肉层收缩以及由此导致的管腔内压力升高是颗粒释放的可能原因；3）在未麻醉的受试者中，释放可能是对正常内源性生理刺激或结肠镜检查期间结肠扩张的反应。在内分泌细胞与相邻细胞之间的侧面观察到某些图像，即围绕分泌颗粒的平行质膜凸起。它们的意义尚不清楚。
