Itzev D, Lolova I, Davidoff M
Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
Anat Anz. 1988;166(1-5):77-85.
The distribution and ultrastructure of the somatostatin-containing endocrine cells in the distal large intestine of fetuses, children and adults was investigated by silver impregnation, immunocytochemical and electron-microscopical techniques. Somatostatin-containing endocrine cells in 10-14-week-old fetuses were found to differentiate very intensively. In 19-25-week-old fetuses the frequency of occurrence began to decrease and this tendency was preserved during the subsequent stages of ontogenesis. Conversely, the frequency of occurrence of argyrophil endocrine cells increased. The change in the mean diameters of the secretory granules was also studied.
采用银染、免疫细胞化学及电子显微镜技术，研究了胎儿、儿童和成人远端大肠中含生长抑素内分泌细胞的分布及超微结构。发现10 - 14周龄胎儿中含生长抑素内分泌细胞分化非常强烈。19 - 25周龄胎儿中其出现频率开始下降，且在个体发育的后续阶段这种趋势持续存在。相反，嗜银内分泌细胞的出现频率增加。还研究了分泌颗粒平均直径的变化。
