自发性高血压大鼠孕期的神经血管功能

Neurovascular function during pregnancy in the spontaneously hypertensive rat.

Yong E M, Mano M T, Head R J

CSIRO Division of Human Nutrition, Adelaide, South Australia.

Clin Exp Pharmacol Physiol. 1992 Jun;19(6):415-23. doi: 10.1111/j.1440-1681.1992.tb00484.x.

Abstract

Blood pressure (BP) declines dramatically in the final week of gestation in the pregnant spontaneously hypertensive rat (SHR). This study investigated the hypothesis that alterations of vascular neuroeffector function in the pregnant SHR and normotensive Wistar-Kyoto (WKY) rat are responsible for this decline. 2. Pregnancy in SHR and WKY rats was associated with a significant drop in BP in the last week of gestation. 3. Responses of the perfused mesenteric vasculature to bolus doses of noradrenaline (NA) and potassium chloride (KCl) were decreased in preparations from SHR rats 4 days before delivery. This decreased responsiveness was absent in preparations from SHR rats 1 day before delivery. Responses of the perfused mesenteric vasculature to sympathetic nerve stimulation were not influenced by pregnancy in the SHR. 4. It is concluded that while there are dynamic changes occurring in neurovascular function just prior to delivery, it is unlikely that they are wholly responsible for the dramatic decline in blood pressure in the SHR rat.

摘要

在妊娠自发性高血压大鼠（SHR）妊娠的最后一周，血压（BP）急剧下降。本研究调查了这样一个假说，即妊娠SHR和正常血压的Wistar-Kyoto（WKY）大鼠血管神经效应功能的改变是导致这种血压下降的原因。2. SHR和WKY大鼠的妊娠在妊娠最后一周与血压显著下降有关。3. 在分娩前4天的SHR大鼠的制备物中，灌注肠系膜血管对大剂量去甲肾上腺素（NA）和氯化钾（KCl）的反应降低。在分娩前1天的SHR大鼠的制备物中不存在这种反应性降低的情况。SHR大鼠中，灌注肠系膜血管对交感神经刺激的反应不受妊娠的影响。4. 得出的结论是，虽然在分娩前神经血管功能会发生动态变化，但它们不太可能是导致SHR大鼠血压急剧下降的全部原因。