Nature. 1979 May 31;279(5712):391-6. doi: 10.1038/279391a0.
Myoplasmic calcium transients in response to pulse depolarisations have been monitored using the dye antipyralazo III, which provides a linear measure of the change in cytoplasmic free calcium concentration. Intramembrane charge movements were recorded simultaneously with the calcium transients. Except for its initial phase, the calcium transient during each pulse closely followed the time course expected for calcium redistribution between three intracellular compartments with time-independent flux coefficients. The time at which the flux coefficients attained their steady values occurred just after the intramembrane charge movement had been completed. This is the required sequence if charge movement were to control one or more coefficients f or calcium fluxes across the sarcoplasmic reliculum membrane.
使用染料安替比林 III 监测了脉冲去极化引起的肌浆钙瞬变，该染料提供了细胞质游离钙浓度变化的线性度量。同时记录了膜内电荷运动和钙瞬变。除了初始相外，每个脉冲期间的钙瞬变都非常接近钙在三个细胞内隔室之间重新分布的时间过程，通量系数与时间无关。通量系数达到稳定值的时间正好在膜内电荷运动完成之后。如果电荷运动控制肌浆网膜上钙通量的一个或多个系数，那么这就是所需的顺序。
