Yan Y S
Chinese Cancer Research Foundation Association, Nanjing Zhongshan Institute.
Zhonghua Yu Fang Yi Xue Za Zhi. 1992 Jan;26(1):5-7.
The dynamic changes of cellular immune function and antitumor effect of GTE (green tea extract) in the BALB/c mice bearing EAC, HAC and S-180 tumor were investigated. Results showed that intraperitoneal injection GTE daily dose of 80mg/kg stimulate the proliferation of T-Lymphocyte S-180 tumor bearing mice, the 125-IudR incorporation value (cpm) of control group was 932 and that of GTE treated group increased to 2988. The Natural Killer cell's activity (cpm) of treated group was raised from 10.7% of control group to 41%. Daily dose 50mg/kg inhibited the EAC, HAC and the life span of GTE mice bearing EAC ascites tumor prolonged 128%. The GTE were effective on growth activity against mouse Ehrlich tumor at a dose of 500mg/kg by oral administration (P less than 0.05), the inhibition ratio being about 32%. The authors suggested the mechanism of antitumor effects of GTE possible included both cellular immune function and the inhibition of tumor growth.
研究了绿茶提取物（GTE）对荷EAC、HAC和S - 180肿瘤的BALB/c小鼠细胞免疫功能和抗肿瘤作用的动态变化。结果表明，每日腹腔注射80mg/kg剂量的GTE可刺激荷S - 180肿瘤小鼠的T淋巴细胞增殖，对照组的¹²⁵-IudR掺入值（cpm）为932，而GTE处理组增加至2988。处理组自然杀伤细胞活性（cpm）从对照组的10.7%提高到41%。每日50mg/kg剂量可抑制EAC、HAC，荷EAC腹水瘤的GTE小鼠寿命延长128%。通过口服给药500mg/kg剂量的GTE对小鼠艾氏瘤的生长活性有效（P小于0.05），抑制率约为32%。作者认为GTE抗肿瘤作用的机制可能包括细胞免疫功能和对肿瘤生长的抑制。
