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In vitro sensitized autologous tumorocidal lymphocytes to colonic adenocarcinoma.

作者信息

Swift R I, Gaer J, Worman C, Thomas M, Habib N A, Wood C B

机构信息

Department of Surgery, Hammersmith Hospital, London, UK.

出版信息

Eur J Surg Oncol. 1992 Jun;18(3):258-63.

PMID:1607038
Abstract

We report a method of developing a population of tumorocidal lymphocytes by culturing peripheral blood mononuclear cells (PBMC) with live isogenic colorectal tumour cells in a mixed cell culture. When the proportion of PBMC to tumour cells is 100:1, eradication of the tumour cell population results. The proportion of activated lymphocytes in culture increases with cytotoxic activity as demonstrated by the presence of the cytotoxic enzyme serine esterase in the lymphocyte granules.

摘要

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