Schubert T T, Schubert A B, Ma C K
Division of Gastroenterology, Henry Ford Hospital, Detroit, Michigan 48202.
Gastrointest Endosc. 1992 May-Jun;38(3):357-60. doi: 10.1016/s0016-5107(92)70432-5.
Acute Helicobacter pylori infection is associated with dyspeptic symptoms but chronic infection has not clearly been shown to cause symptoms. To define further the role of H. pylori infection and gastritis in dyspepsia, we interviewed all patients about to undergo upper endoscopy, recorded the primary indication for endoscopy, noted the endoscopic findings, and obtained antral biopsies. Among non-ulcer patients there was a strong correlation of acute gastritis with H. pylori. Gastritis and H. pylori increased with age, and non-steroidal anti-inflammatory drug use correlated with normal histology. Neither H. pylori concentration nor gastritis grade correlated with gender, use of alcohol and tobacco, indication for endoscopy, or symptoms (epigastric pain, nausea, vomiting, bloating, belching, heartburn, halitosis, and flatulence).
急性幽门螺杆菌感染与消化不良症状相关，但慢性感染尚未明确显示会引起症状。为进一步明确幽门螺杆菌感染和胃炎在消化不良中的作用，我们对所有即将接受上消化道内镜检查的患者进行了访谈，记录内镜检查的主要指征，记录内镜检查结果，并获取胃窦活检样本。在非溃疡患者中，急性胃炎与幽门螺杆菌感染之间存在很强的相关性。胃炎和幽门螺杆菌感染率随年龄增长而增加，使用非甾体抗炎药与正常组织学相关。幽门螺杆菌浓度和胃炎分级均与性别、烟酒使用、内镜检查指征或症状（上腹痛、恶心、呕吐、腹胀、嗳气、烧心、口臭和气胀）无关。
