Ellis I O, Galea M, Broughton N, Locker A, Blamey R W, Elston C W
Department of Histopathology, City Hospital, Nottingham, UK.
Histopathology. 1992 Jun;20(6):479-89. doi: 10.1111/j.1365-2559.1992.tb01032.x.
The histological tumour type determined by current criteria has been investigated in a consecutive series of 1621 women with primary operable breast carcinoma, presenting between 1973 and 1987. All women underwent definitive surgery with node biopsy and none received adjuvant systemic therapy. Special types, tubular, invasive cribriform and mucinous, with a very favourable prognosis can be identified. A common type of tumour recognized by our group and designated tubular mixed carcinoma is shown to be prognostically distinct from carcinomas of no special type; it has a characteristic histological appearance and is the third most common type in this series. Analysis of subtypes of lobular carcinoma confirms differing prognoses. The classical, tubulo-lobular and lobular mixed types are associated with a better prognosis than carcinomas of no special type; this is not so for the solid variant. Tubulo-lobular carcinoma in particular has an extremely good prognosis similar to tumours included in the 'special type' category above. Neither medullary carcinoma nor atypical medullary carcinoma are found to carry a survival advantage over carcinomas of no special type. The results confirm that histological typing of human breast carcinoma can provide useful prognostic information.
对1973年至1987年间连续收治的1621例原发性可手术乳腺癌女性患者，依据当前标准确定了组织学肿瘤类型。所有女性均接受了根治性手术及淋巴结活检，且均未接受辅助性全身治疗。可以识别出预后非常良好的特殊类型，如管状癌、浸润性筛状癌和黏液癌。我们团队识别出的一种常见肿瘤类型，称为管状混合癌，其预后与非特殊类型的癌不同；它具有特征性的组织学表现，是该系列中第三常见的类型。对小叶癌亚型的分析证实了不同的预后情况。经典型、小管小叶型和小叶混合型的预后优于非特殊类型的癌；实性变体则不然。特别是小管小叶癌的预后非常好，与上述“特殊类型”类别的肿瘤相似。未发现髓样癌和非典型髓样癌比非特殊类型的癌具有生存优势。结果证实，人类乳腺癌的组织学分型可提供有用的预后信息。
