du Toit R S, Locker A P, Ellis I O, Elston C W, Nicholson R I, Blamey R W
Department of Surgery, City Hospital, Nottingham, UK.
Br J Cancer. 1989 Oct;60(4):605-9. doi: 10.1038/bjc.1989.323.
One hundred and seventy-one cases of operable invasive lobular carcinoma, presenting over an 11-year period, were reviewed. Histological subtypes were investigated to determine differences in their clinical behaviour and whether these differences could be explained by histopathological features. Five subtypes were identified: mixed (45.6%), classical (30.4%), tubulo-lobular (13.5%), solid (6.4%) and alveolar (4.1%). The median follow-up period was 64 months and the median age 54 years. The 12-year actuarial survival rate was 100% for the tubulo-lobular subtype, but only 47% for the solid variant. Similar differences were found in the disease free interval, locoregional and distant metastatic rates between these two subtypes. The tubulo-lobular tumours were more likely to be of good histological grade and node negative. The other three subtypes did not differ significantly in their histopathological parameters, reflected in similar clinical behaviour. They occupied an intermediate position between the other two subtypes in terms of prognosis.
对11年间出现的171例可手术切除的浸润性小叶癌病例进行了回顾性研究。研究了组织学亚型，以确定它们在临床行为上的差异，以及这些差异是否可以通过组织病理学特征来解释。确定了五种亚型：混合型（45.6%）、经典型（30.4%）、小管小叶型（13.5%）、实体型（6.4%）和腺泡型（4.1%）。中位随访期为64个月，中位年龄为54岁。小管小叶型亚型的12年精算生存率为100%，而实体变型仅为47%。在这两种亚型之间的无病间期、局部区域和远处转移率方面也发现了类似的差异。小管小叶型肿瘤更可能具有良好的组织学分级且无淋巴结转移。其他三种亚型在组织病理学参数上没有显著差异，这反映在相似的临床行为上。在预后方面，它们处于其他两种亚型之间的中间位置。
