Kitanaka Nobue, Kitanaka Junichi, Takemura Motohiko
Department of Pharmacology, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663-8501 Nishinomiya, Hyogo, Japan.
Neurochem Res. 2005 Apr;30(4):445-51. doi: 10.1007/s11064-005-2679-z.
Following the expression of the behavioral sensitization by repeated administration of methamphetamine (METH) (1 mg/kg, intraperitoneal (i.p.), once per day for five consecutive days), male ICR mice were treated with clorgyline (1 mg/kg, subcutaneous, once per day for five consecutive days), a monoamine oxidase-A inhibitor. Two hours after the final treatment with clorgyline, the mice were challenged with METH (1 mg/kg, i.p.) and locomotor activity was measured for 1 h. The mice treated with clorgyline showed a significant decrease in both vertical locomotion and horizontal rearing, compared with those treated with saline. Clorgyline treatment altered the effect of single METH challenges on apparent dopamine turnover in the cerebral cortex of the mice sensitized to METH. These results suggested a possible association of the inhibition by clorgyline of METH-induced behavioral sensitization with the alteration of dopamine turnover in the cerebral cortex of the mouse.
通过连续五天每天腹腔注射（i.p.）1毫克/千克甲基苯丙胺（METH）诱导雄性ICR小鼠产生行为敏化后，用单胺氧化酶-A抑制剂氯吉兰（1毫克/千克，皮下注射，连续五天每天一次）对其进行处理。在最后一次给予氯吉兰两小时后，用METH（1毫克/千克，腹腔注射）对小鼠进行激发，并测量其运动活性1小时。与用生理盐水处理的小鼠相比，用氯吉兰处理的小鼠在垂直运动和水平竖毛行为上均显著减少。氯吉兰处理改变了单次METH激发对METH致敏小鼠大脑皮层中表观多巴胺周转率的影响。这些结果表明，氯吉兰对METH诱导的行为敏化的抑制作用可能与小鼠大脑皮层中多巴胺周转率的改变有关。
