Mamontova O A, Protsenko D N, Eliutin D V, Kirienko P N, Gel'fand B R
Anesteziol Reanimatol. 2005 May-Jun(3):42-5.
Exogenous activated protein C combines a marked anti-inflammatory effect on the vascular endothelium and anticoagulative and profibrinolytic activities. The total results of this action are better multiple organ microcirculation and, as a result, elimination and even prevention of irreversible changes in the vitally important organs. The many-sidedness and potency of this effect make the agent essential for intensive therapy of severe sepsis of various etiology. The Russian cooperative study of the efficacy of the exogenous activated protein C--drotrecogine alpha (activated)--has shown that its inclusion into therapy for sepsis with multiple organ dysfunction and septic shock results in longer estimated survival. With this, the best results are observed when therapy is initiated within 48 hours since the development of multiple organ deficiency.
外源性活化蛋白C对血管内皮具有显著的抗炎作用，并兼具抗凝和促纤溶活性。这一作用的总体结果是改善多器官微循环，从而消除甚至预防重要器官的不可逆变化。这种作用的多面性和强效性使该药物成为各种病因所致严重脓毒症强化治疗的关键药物。俄罗斯对外源性活化蛋白C（重组人活化蛋白C）疗效的合作研究表明，将其用于伴有多器官功能障碍和感染性休克的脓毒症治疗可延长预计生存期。在此情况下，自多器官功能不全发生起48小时内开始治疗时观察到的效果最佳。
