Dimo T, Ntchapda F, Atchade A T, Yewah M P, Kamtchouing P, Ngassam P
Department of Animal Biology and Physiology, Faculty of Science, PO. Box 812 University of Yaounde I, Cameroon.
Pharmazie. 2005 Jul;60(7):548-50.
Celtis durandii is a medicinal plant widely used in some part of Cameroon for the treatment of cardiovascular disorders. The vasorelaxant effects of the methylene chloride/methanol leaf extract of C. durandii were examined on isolated rat thoracic aorta. The relaxant effects of C. durandii on vascular preparation from rat aorta precontracted with KCl or norepinephrine was concentration dependent. This relaxing effect was significantly reduced with KCl-induced contraction following mechanical damage to the aortic endothelium. Relaxation elicited by C. durandii was not significantly affected by glibenclamide (10(-6) M), a selective inhibitor of K-ATP-dependent channels or tetraethylammonium (10(-6) M), a non selective K+ channel blocker. Indomethacin (10(-6) M) significantly inhibited relaxation induced by the plant extract. These findings indicate that the vasorelaxation effect of the methylene chloride/methanol leaf extract of C. durandii may be mediated at least in part by prostacyclin.
杜氏朴树是一种药用植物，在喀麦隆的一些地区被广泛用于治疗心血管疾病。研究了杜氏朴树二氯甲烷/甲醇叶提取物对离体大鼠胸主动脉的血管舒张作用。杜氏朴树对氯化钾或去甲肾上腺素预收缩的大鼠主动脉血管标本的舒张作用呈浓度依赖性。在主动脉内皮受到机械损伤后，氯化钾诱导的收缩使这种舒张作用显著降低。杜氏朴树引起的舒张不受格列本脲（10⁻⁶ M）（一种K⁺-ATP依赖性通道的选择性抑制剂）或四乙铵（10⁻⁶ M）（一种非选择性K⁺通道阻滞剂）的显著影响。吲哚美辛（10⁻⁶ M）显著抑制了植物提取物诱导的舒张。这些发现表明，杜氏朴树二氯甲烷/甲醇叶提取物的血管舒张作用可能至少部分是由前列环素介导的。
