Marcano Ana C B, Onipinla Abiodun K, Caulfield Mark J, Munroe Patricia B
Clinical Pharmacology and The Genome Centre, The William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, UK.
Expert Rev Cardiovasc Ther. 2005 Jul;3(4):733-41. doi: 10.1586/14779072.3.4.733.
It is a well-established fact that genes are involved in the etiology of hypertension. However, identification of the gene variants still remains a challenge. Over the years, different approaches and technologies, including genome-wide scans, case-control association studies, experiments on inbred rodent models and expression profiling, have been utilized to elucidate hypertension susceptibility genes, but so far the results have been equivocal. During the last year, further chromosomal regions harboring blood pressure loci have been identified, and transcriptomics has been applied to aid the identification of disease genes. There are great expectations for the future with regards to further advancements in transcriptomics and proteomics. This review reports primarily on work that has been carried out in the last 12 months in the field, and considers its contribution towards a better understanding of the genetic mechanisms involved in blood pressure regulation and hypertension.
基因参与高血压的病因已成为既定事实。然而，鉴定基因变异仍然是一项挑战。多年来，人们利用了不同的方法和技术，包括全基因组扫描、病例对照关联研究、近交啮齿动物模型实验和表达谱分析，来阐明高血压易感基因，但迄今为止结果尚无定论。在过去一年中，已鉴定出更多含有血压基因座的染色体区域，转录组学也已应用于辅助疾病基因的鉴定。人们对转录组学和蛋白质组学的未来进一步发展寄予厚望。本综述主要报道了该领域过去12个月所开展的工作，并探讨了其对更好地理解血压调节和高血压所涉及的遗传机制的贡献。
