Thompson Charlie S, Hakim Antoine M
Neuroscience Research Program, Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario.
Mol Neurobiol. 2005 Aug;32(1):51-7. doi: 10.1385/MN:32:1:051.
As more information becomes available regarding the role of inflammation following stroke, it is apparent that some inflammatory mediators are detrimental and others are beneficial to the progression of ischemic injury. Cortical spreading depression (CSD) is known to impart some degree of ischemic tolerance to the brain and to influence the expression of many genes. Many of the genes whose expression is altered by CSD are associated with inflammation, and it appears likely that modulation of the inflammatory response to ischemia by CSD contributes to ischemic tolerance. Understanding which inflammatory processes are influenced by CSD may lead to the identification of novel targets in the effort to develop an acute treatment for stroke.
随着越来越多关于中风后炎症作用的信息被获取，很明显一些炎症介质对缺血性损伤的进展是有害的，而另一些则是有益的。已知皮质扩散性抑制（CSD）能赋予大脑一定程度的缺血耐受性并影响许多基因的表达。许多其表达因CSD而改变的基因都与炎症相关，并且CSD对缺血炎症反应的调节似乎有助于缺血耐受性。了解哪些炎症过程受CSD影响可能会在开发中风急性治疗方法的努力中促成新靶点的识别。
