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玻璃体内注射曲安奈德作为视网膜分支静脉阻塞继发黄斑囊样水肿的主要治疗方法。

Intravitreal triamcinolone as primary treatment of cystoid macular edema secondary to branch retinal vein occlusion.

作者信息

Lee Henry, Shah Gaurav K

机构信息

Barnes Retina Institute and Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri 63144, USA.

出版信息

Retina. 2005 Jul-Aug;25(5):551-5. doi: 10.1097/00006982-200507000-00001.

Abstract

PURPOSE

To describe six patients treated with intravitreal triamcinolone (IVT) as primary therapy for cystoid macular edema (CME) secondary to branch retinal vein occlusion (BRVO).

METHODS

Retrospective case series.

RESULTS

The age of the patients ranged from 53 years to 87 years (mean, 66 years). The time between BRVO and treatment with IVT ranged from 2.0 months to 4.7 months (mean, 3.5 months). Pretreatment visual acuity ranged from 20/40 to 6/200 (mean, 20/166). Length of follow-up ranged from 107 days to 175 days (mean, 149.5 days). Final visual acuity ranged from 20/40 to 3/200 (mean, 20/137). Three of six eyes showed improvement in vision. All three patients who did not have vision improvement were treated with a second injection. At the final follow-up visit, all six eyes had improved vision from baseline. Five (83.3%) of six eyes showed an improvement of > or = 2 lines of vision. One patient had a postoperative rise in intraocular pressure requiring a trabeculectomy. Final visual acuity in the 6 eyes ranged from 20/200 to 20/30 (mean, 20/106).

CONCLUSION

IVT may be of potential use in treating CME due to BRVO, as either a primary or an adjunctive treatment modality. A prospective, randomized trial to clarify this role is warranted.

摘要

目的

描述6例接受玻璃体内注射曲安奈德(IVT)作为视网膜分支静脉阻塞(BRVO)继发黄斑囊样水肿(CME)主要治疗方法的患者情况。

方法

回顾性病例系列研究。

结果

患者年龄从53岁至87岁不等(平均66岁)。BRVO与IVT治疗之间的时间间隔从2.0个月至4.7个月不等(平均3.5个月)。治疗前视力从20/40至6/200不等(平均20/166)。随访时间从107天至175天不等(平均149.5天)。最终视力从20/40至3/200不等(平均20/137)。6只眼中有3只视力改善。3例视力未改善的患者均接受了第二次注射。在最后一次随访时,所有6只眼的视力均较基线有所改善。6只眼中有5只(83.3%)视力提高了≥2行。1例患者术后眼压升高,需要进行小梁切除术。6只眼的最终视力从20/200至20/30不等(平均20/106)。

结论

IVT作为主要或辅助治疗方式,在治疗BRVO所致CME方面可能具有潜在用途。有必要进行一项前瞻性随机试验以明确其作用。

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