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裸鼠人肿瘤异种移植的实验性热放疗:热疗系统的设计

Experimental thermoradiotherapy of human tumour xenografts in nude mice: design of the hyperthermia system.

作者信息

Bruggmoser G, Hinkelbein W, Saum R

机构信息

Department of Radiotherapy, University Hospital, Freiburg, Germany.

出版信息

Int J Hyperthermia. 1992 May-Jun;8(3):363-75. doi: 10.3109/02656739209021791.

DOI:10.3109/02656739209021791
PMID:1607741
Abstract

An experimental thermoradiotherapy study was started in 1986. For this study a hyperthermia system was developed for the heating of human tumours xenotransplanted into nude mice. Our treatment device was a four-channel computer-controlled hyperthermia system. Temperature was monitored by microwave radiometry at 3 GHz. Specifications of the radiometer were first evaluated under reference conditions, then thermal dosimetry was studied using non-invasive measurement of the brightness temperature TOR. Hyperthermia treatments were simulated in phantom material with radiometric monitor values TR of 40 and 41. In conjunction with the parameters of brightness temperature TOR, surface temperature TO and water bolus temperature TW thermal modelling was performed. Finally, we studied the influence of a perfused phantom to the microwave thermometry.

摘要

一项实验性热放疗研究始于1986年。为了这项研究,开发了一种用于加热移植到裸鼠体内的人类肿瘤的热疗系统。我们的治疗设备是一个四通道计算机控制的热疗系统。通过3GHz的微波辐射测量法监测温度。首先在参考条件下评估辐射计的规格,然后使用亮度温度TOR的非侵入性测量研究热剂量测定。在体模材料中模拟热疗治疗,辐射监测值TR为40和41。结合亮度温度TOR、表面温度TO和水垫温度TW的参数进行热模拟。最后,我们研究了灌注体模对微波测温的影响。

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