Oohira A, Iwashita M, Takeda Y, Sakamoto S
Department of Obstetrics and Gynecology, Tokyo Women's Medical College.
Nihon Sanka Fujinka Gakkai Zasshi. 1992 Mar;44(3):275-81.
To elucidate the physiological significance of epidermal growth factor (EGF) in fetal and placental development, the effects of neutralization of circulating EGF by anti-EGF antiserum on fetal and placental development were evaluated in pregnant mice. Abdominally administrated antiserum neutralized EGF in fetal and maternal circulation. Fetal weight was not affected by anti-EGF antiserum, but placental weight was suppressed when antiserum was administrated in the latter half of pregnancy. There was no significant difference between control and antiserum injected mice in the affinity and capacity of EGF receptor in the placenta. The number and volume of lamellar bodies were significantly decreased in antiserum treated mice at Day 10-18 compared to control mice. These results suggest that EGF is involved in placental development, especially in late pregnancy. Furthermore, EGF in the circulation may contribute to enhancing fetal lung maturity rather than fetal growth.
为阐明表皮生长因子（EGF）在胎儿及胎盘发育中的生理意义，我们在怀孕小鼠中评估了抗EGF抗血清中和循环中的EGF对胎儿及胎盘发育的影响。经腹部给予的抗血清可中和胎儿及母体循环中的EGF。胎儿体重不受抗EGF抗血清的影响，但在妊娠后半期给予抗血清时，胎盘重量受到抑制。注射抗血清的小鼠与对照小鼠在胎盘EGF受体的亲和力和结合能力方面无显著差异。与对照小鼠相比，在第10至18天，抗血清处理的小鼠中板层小体的数量和体积显著减少。这些结果表明，EGF参与胎盘发育，尤其是在妊娠晚期。此外，循环中的EGF可能有助于促进胎儿肺成熟而非胎儿生长。
