Möller Hans-Jürgen, Grunze Heinz, Broich Karl
Department of Psychiatry, Ludwig-Maximilians-University, Nussbaumstrasse 7, 80336 Munich, Germany.
Eur Arch Psychiatry Clin Neurosci. 2006 Feb;256(1):1-16. doi: 10.1007/s00406-005-0591-9. Epub 2005 Aug 4.
This conceptual review summarises the results of relevant studies on antidepressants, mood stabilisers such as lithium and anticonvulsants, and second generation antipsychotics in the indication of bipolar depression. Based on methodological and clinical considerations, the position of antidepressants and the possible alternatives in this indication are reviewed very carefully. In addition the regulatory requirements for licensing a drug for the indication "short-term treatment of bipolar depression" are described.
这篇概念性综述总结了关于抗抑郁药、锂盐等心境稳定剂和抗惊厥药以及第二代抗精神病药物用于双相抑郁适应症的相关研究结果。基于方法学和临床方面的考量，对抗抑郁药在此适应症中的地位以及可能的替代药物进行了非常仔细的审查。此外，还描述了药物获批“双相抑郁短期治疗”适应症的监管要求。
