Il'ina-Kakueva E I
Aviakosm Ekolog Med. 2005 Mar-Apr;39(2):38-41.
Dynamics of the 60-d soleus recovery was studied morphologically and histomorphometrically in female rats exposed to 30-d tail-suspension. Suspension led to soleus atrophy manifested by substantial losses in mass (56% vs. the control) and cross-sectional area of myofibers, and partial transformation of slow fibers into fast. The most intensive recovery processes in the soleus, reverse to the atrophic ones, were observed in the period between days 2 and 8 of readaptation, but then they subsided. Full recovery of the soleus mass and CSA took approximately 60 days of readaptation. Fast myofibers are less susceptible to atrophy and, therefore, recovered sooner than the slow ones. Percentage of slow-to-fast fibers returned to the norm between days 14 and 30. In addition to the persisting atrophy on readaptation day 2, there were some hemodynamic disorders in the soleus fraught with interstitial edema, distortion of muscle trophism, dystrophic developments in muscle fibers, and death of a number of fibers. Edema faded away between days 8 and 14 of readaptation. Recovery of the soleus muscle was considerably compromised by hemodynamic disorders at the beginning of readaptation.
对暴露于30天尾部悬吊的雌性大鼠，从形态学和组织形态计量学方面研究了60天比目鱼肌的恢复动态。悬吊导致比目鱼肌萎缩，表现为质量（比对照组减少56%）和肌纤维横截面积大幅损失，以及慢肌纤维部分转变为快肌纤维。在重新适应的第2天至第8天期间观察到比目鱼肌中最强烈的恢复过程，这与萎缩过程相反，但随后恢复过程减缓。比目鱼肌质量和横截面积的完全恢复大约需要60天的重新适应时间。快肌纤维对比萎缩不太敏感，因此比慢肌纤维恢复得更快。慢肌纤维向快肌纤维的百分比在第14天至第30天恢复正常。除了在重新适应第2天持续存在的萎缩外，比目鱼肌还存在一些血液动力学紊乱，伴有间质水肿、肌肉营养失调、肌纤维营养不良性变化以及一些纤维死亡。水肿在重新适应的第8天至第14天消退。重新适应开始时的血液动力学紊乱严重损害了比目鱼肌的恢复。
