[正电子发射断层扫描在脑肿瘤复发生长诊断中的应用]

[Positron emission tomography in the diagnosis of recurrent growth of brain tumors].

作者信息

Skvortsova T Iu, Brodskaia Z L, Rudas M S, Mozhaev S V, Gurchin A F, Medvedev S V

出版信息

Zh Vopr Neirokhir Im N N Burdenko. 2005 Apr-Jun(2):3-7; discussion 7.

Abstract

The authors analyzed the results of 11C-methionine positron emission tomography (PET) in 101 patients with suspected recurrent brain tumor. The diagnosis was confirmed in 72 patients. The increased 11C-methionine uptake in the initial tumor area is considered to be a crucial PET evidence of a recurrent tumor. On the other hand, brain tissue histological changes associated with surgery, radiation, and chemotherapy were characterized by the low uptake of the tracer. The sensitivity and specificity of PET scanning in detecting tumor recurrence were found to be 95.8 and 96.5%, respectively. 11C-methionine PET is proposed as a reliable technique for early differentiating between a recurrent brain tumor and treatment-induced nonneoplastic changes.

摘要

作者分析了101例疑似复发性脑肿瘤患者的11C-蛋氨酸正电子发射断层扫描（PET）结果。72例患者确诊。初始肿瘤区域11C-蛋氨酸摄取增加被认为是复发性肿瘤的关键PET证据。另一方面，与手术、放疗和化疗相关的脑组织组织学变化表现为示踪剂摄取低。PET扫描检测肿瘤复发的敏感性和特异性分别为95.8%和96.5%。11C-蛋氨酸PET被认为是一种可靠的技术，可用于早期鉴别复发性脑肿瘤和治疗引起的非肿瘤性变化。