Sadeghi Niloufar, Salmon Isabelle, Tang Bich Ngoc Thanh, Denolin Vincent, Levivier Marc, Wikler David, Rorive Sandrine, Balériaux Danielle, Metens Thierry, Goldman Serge
Department of Radiology, Hôpital Erasme, Brussels, Belgium.
J Magn Reson Imaging. 2006 Nov;24(5):989-94. doi: 10.1002/jmri.20757.
To evaluate in brain gliomas the relationship between tumor vascularity measured by MR-based maximum regional cerebral blood volume (rCBV) and tumor amino-acid metabolism based on maximum carbon-11 methionine (MET) uptake on positron emission tomography (PET).
Eighteen patients with histologically proven primary brain gliomas were included in the study. In addition to conventional MR sequences, dynamic MR images, including a first-pass gadopentetate dimeglumine T2*-weighted echo-planar perfusion sequence and a PET study using MET, were acquired. Eleven patients had low-grade gliomas, and seven had high-grade gliomas. rCBV ratios and MET uptake ratios normalized to the contralateral white matter (WM) corresponding values were measured in each tumor. Both maximum rCBV ratios and maximum MET uptake ratios were correlated to histopathology. The maximum rCBV ratios were correlated to the maximum MET uptake ratios.
Both the maximum rCBV ratios and maximum MET uptake ratios of high-grade gliomas were significantly higher than those of low-grade gliomas (P<0.05). There was a significant positive correlation between maximum rCBV ratios and maximum MET uptake ratios (Spearman: r=0.89, P<0.00001).
The maximum rCBV ratio and maximum MET uptake ratio are significantly correlated in gliomas, reflecting a close link between amino acid uptake and vascularity in these tumors.
评估在脑胶质瘤中，基于磁共振成像（MR）测量的最大局部脑血容量（rCBV）所反映的肿瘤血管生成与基于正电子发射断层扫描（PET）上最大碳-11蛋氨酸（MET）摄取所反映的肿瘤氨基酸代谢之间的关系。
本研究纳入18例经组织学证实的原发性脑胶质瘤患者。除常规MR序列外，还采集了动态MR图像，包括首过钆喷酸葡胺T2*加权回波平面灌注序列和使用MET的PET研究。11例患者为低级别胶质瘤，7例为高级别胶质瘤。在每个肿瘤中测量rCBV比值和以对侧白质（WM）相应值标准化的MET摄取比值。最大rCBV比值和最大MET摄取比值均与组织病理学相关。最大rCBV比值与最大MET摄取比值相关。
高级别胶质瘤的最大rCBV比值和最大MET摄取比值均显著高于低级别胶质瘤（P<0.05）。最大rCBV比值与最大MET摄取比值之间存在显著正相关（Spearman：r=0.89，P<0.00001）。
在胶质瘤中，最大rCBV比值与最大MET摄取比值显著相关，反映了这些肿瘤中氨基酸摄取与血管生成之间的密切联系。
