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1年内健康和功能下降的程度及模式会影响随后5年的生存率。

Magnitude and patterns of decline in health and function in 1 year affect subsequent 5-year survival.

作者信息

Perera Subashan, Studenski Stephanie, Chandler Julie M, Guralnik Jack M

机构信息

University of Kansas Medical Center, Kansas City, USA.

出版信息

J Gerontol A Biol Sci Med Sci. 2005 Jul;60(7):894-900. doi: 10.1093/gerona/60.7.894.

Abstract

BACKGROUND

Indicators of physical function and health status can predict important outcomes in older persons, but little is known about the meaning of change in these measures. This study assessed the magnitude and patterns of change occurring in 1 year in six measures of health and function and estimated the effects on survival for 5 years.

METHODS

This prospective cohort study was based in two health care systems. Data were collected during home visits at baseline and every 3 months for 1 year. Subsequent deaths occurring within 5 years were ascertained using the National Death Index.

RESULTS

Of 439 older adults, 88 (20%) died within the subsequent 5 years. The optimal magnitude of decline to predict 5-year mortality was 0.1 meters/second for gait speed, 1 point for the Short Physical Performance Battery, and 0.05 points for Euroqol. Independent contributions were found for decline in gait speed (p =.001 to.002), Short Physical Performance Battery (p =.014 to.026), global health (p <.001), and activities of daily living (p =.005 to.019). More than one half of the episodes of decline were transient. Persistent decline in 1 year consistently predicted death, and transient decline in gait speed and global health increased mortality risk compared with no change.

CONCLUSIONS

A decline in gait speed of 0.1 m/s or 1 point in the Short Physical Performance Battery within 1 year increased the subsequent 5-year mortality rate. Transient declines in gait speed and self-reported health are as common as persistent declines and affect mortality risk.

摘要

背景

身体功能和健康状况指标可预测老年人的重要预后,但对于这些指标变化的意义知之甚少。本研究评估了六项健康和功能指标在1年内发生变化的幅度和模式,并估计了其对5年生存率的影响。

方法

这项前瞻性队列研究基于两个医疗保健系统。在基线时以及之后1年中每3个月进行家访时收集数据。使用国家死亡指数确定随后5年内发生的死亡情况。

结果

439名老年人中,88人(20%)在随后5年内死亡。预测5年死亡率的最佳下降幅度为:步速0.1米/秒,简短体能测试1分,欧洲五维度健康量表0.05分。发现步速下降(p = 0.001至0.002)、简短体能测试下降(p = 0.014至0.026)、整体健康下降(p < 0.001)和日常生活活动能力下降(p = 0.005至0.019)具有独立的预测作用。超过一半的下降情况是短暂的。1年内持续下降始终可预测死亡,与无变化相比,步速和整体健康的短暂下降会增加死亡风险。

结论

1年内步速下降0.1米/秒或简短体能测试下降1分,会增加随后5年的死亡率。步速和自我报告健康状况的短暂下降与持续下降一样常见,并会影响死亡风险。

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